Antibiotics Aren't Always the Answer

Nov 2012

Antibiotics do not fight infections caused by viruses like colds, most sore throats and bronchitis, and some ear infections. Unneeded antibiotics may lead to future antibiotic-resistant infections. Symptom relief might be the best treatment option.

Dangers of Antibiotic Resistance

Colds and many other upper respiratory infections, as well as some ear infections, are caused by viruses, not bacteria. If antibiotics are used too often for things they can't treat—like colds or other viral infections—they can stop working effectively against bacteria when you or your child really needs them. Antibiotic resistance—when antibiotics can no longer cure bacterial infections—has been a concern for years and is considered one of the world's most critical public health threats.

CDC efforts have resulted in fewer children receiving unnecessary antibiotics in recent years, but inappropriate use remains a problem. Widespread overuse and inappropriate use of antibiotics continues to fuel an increase in antibiotic-resistant bacteria.So the next time you or your child really needs an antibiotic for a bacterial infection, it may not work.

Antibiotic resistance is also an economic burden on the entire healthcare system. Resistant infections cost more to treat and can prolong healthcare use.

If You or Your Child Has a Virus Like a Cold or Sore Throat

Taking antibiotics when you or your child has a virus may do more harm than good. In fact, in children, antibiotics are the most common cause of emergency department visits for adverse drug events. Rest, fluids, and over-the-counter products may be your or your child's best treatment option.

Get smart about when antibiotics are appropriate—to fight bacterial infections. Taking them for viral infections, such as a cold, most sore throats, acute bronchitis and many sinus or ear infections:

• Will not cure the infection
• Will not keep other people from getting sick
• Will not help you or your child feel better
• May cause unnecessary and harmful side effects

What Not to Do

• Do not demand antibiotics when a doctor says they are not needed.
• Do not take an antibiotic for a viral infection like a cold or most sore throats.
• Do not take antibiotics prescribed for someone else. The antibiotic may not be right for your or your child's illness. Taking the wrong medicine may delay correct treatment and allow bacteria to increase.

If your doctor prescribes an antibiotic for bacterial infection:

• Do not skip doses.
• Do not save any of the antibiotics for the next time you or your child gets sick.

What to Do

Just because your doctor doesn't give you an antibiotic doesn't mean you aren't sick.

Talk with your doctor about the best treatment for your or your child's illness. To feel better when you or your child has an upper respiratory infection:

• Ask your doctor or pharmacist about over-the-counter treatment options that may help reduce symptoms
• Increase fluid intake
• Get plenty of rest
• Use a cool-mist vaporizer or saline nasal spray to relieve congestion
• Soothe a throat with ice chips, sore throat spray, or lozenges (do not give lozenges to young children)

Video: Parents Want To Do What’s Best

When your child is sick, antibiotics may not be the answer. Work with your child's doctor or nurse to learn how you can help your child feel better. CDC created a 30-second TV public service announcement to highlight this important information.

CDC 

Maine Voices: How antibiotics can make us sicker

Maine Voices: How antibiotics can make us sicker

Sun. Nov 11, 2012

By Dr. Stephen Sears, state epidemiologist 

AUGUSTA – The Maine Center for Disease Control and Prevention, Maine doctors and Maine hospitals have news for parents this cold and flu season: Antibiotics don't work for a cold or the flu.

Antibiotics kill bacteria, not viruses. And colds, flu and most sore throats are caused by viruses. Antibiotics don't touch viruses – never have, never will. And it's not really news. It's a long-documented medical fact.

But tell that to parents seeking relief for a child's runny nose. Research shows that most Americans have either missed the message about appropriate antibiotic use or they simply don't believe it.

According to public opinion research, there is a perception that "antibiotics cure everything."

Americans believe in the power of antibiotics so much that patients go to the doctor expecting to get a prescription. And many do. Three out of 10 children who visit an outpatient provider with the common cold receive an antibiotic. This is an improvement from previous years, but antibiotics are not indicated for a common cold.

Why does this happen? Physicians often are too pressured for time to engage in lengthy explanations of why antibiotics won't work. And when the diagnosis is uncertain – as many symptoms for viral and bacterial infections are similar – doctors are more likely to yield to patient demands for antibiotics.

The problem is, taking antibiotics when they are not needed can do more harm than good. Widespread inappropriate use of antibiotics is one of the major reasons for an increase in drug-resistant bacteria. Families and entire communities feel the impact when disease-causing germs become resistant to antibiotics.

The most obvious consequence of inappropriate antibiotic use is its effect on the sick patient. When antibiotics are incorrectly used to treat children or adults with viral infections, such as colds and flu, they aren't getting the best care for their condition. A course of antibiotics won't fight the virus, make the patient feel better, yield a quicker recovery or keep others from getting sick.

Antibiotics also can have serious side effects ranging from nausea, vomiting and diarrhea to life-threatening allergic reactions.

A less obvious consequence of antibiotic overuse is the boost it gives to drug-resistant disease-causing bacteria. Almost every type of bacteria has become less responsive to antibiotic treatment when it really is needed. These antibiotic-resistant bacteria can quickly spread to relatives, classmates and co-workers – threatening the community with a new strain of infectious disease that is more difficult to cure and more expensive to treat.

For example, cases of H1N1 flu have shown resistance to oseltamivir, one of only two antivirals that work against it. Methicillin-resistant Staphylococcus aureus, known as MRSA, remains a problem in many health care settings and can be life-threatening for patients who have weakened immune systems. Even the common sexually transmitted disease gonorrhea is now showing potential for resistance to cephalosporins, the only recommended antibiotic left to treat this infection.

Antibiotic resistance increases the economic burden on the entire health care system. Resistant infections are often more severe, leading to longer hospital stays and increased costs for treatment.

According to the latest available data, antibiotic resistance in the United States costs an estimated $20 billion a year in excess health care costs, $35 million in other societal costs and more than 8 million additional days that people spend in the hospital.

The U.S. Centers for Disease Control and Prevention has stated that antibiotic resistance is one of the world's most pressing public health problems. For this reason, the Maine CDC, the Maine Medical Association, the Maine Hospital Association, the Maine Osteopathic Association and the Maine Public Health Association have joined with the U.S. CDC to recognize Nov. 12-18 as Get Smart About Antibiotics Week.

Americans of all ages can lower this risk by talking to their doctors and using antibiotics appropriately during this cold and flu season.

Maine Sunday Telegram

The Novel Biological Action of Antimicrobial Peptides via Apoptosis Induction.

Nov 2012

Cho J, Hwang IS, Choi H, Hwang JH, Hwang JS, Lee DG.

Source

School of Life Sciences and Biotechnology, College of Natural Sciences, Kyungpook National University, Daegu 702-701, Korea.

Abstract

Antimicrobial peptides (AMPs) exert antimicrobial activity against Gram-positive and Gram-negative bacteria, fungi, and viruses by various mechanisms. AMPs commonly possess particular characteristics by harboring cationic and amphipathic structures and binding to cell membranes, resulting in the leakage of essential cell contents by forming pores or disturbing lipid organization. These membrane disruptive mechanisms of AMPs are possible to explain according to the various structure forming pores in the membrane. Some AMPs inhibit DNA and/or RNA synthesis as well as apoptosis induction by reactive oxygen species (ROS) accumulation and mitochondrial dysfunction. Specifically, mitochondria play a major role in the apoptotic pathway. During apoptosis induced by AMPs, cells undergo cytochrome c release, caspase activation, phosphatidylserine externalization, plasma or mitochondrial membrane depolarization, DNA and nuclei damage, cell shrinkage, apoptotic body formation, and membrane blebbing. Even AMPs, which have been reported to exert membrane-active mechanisms, induce apoptosis in yeast. These phenomena were also discovered in tumor cells treated with AMPs. The apoptosis mechanism of AMPs is available for various therapeutics such as antibiotics for antibiotic-resistant pathogens that resist to the membrane active mechanism, and antitumor agents with selectivity to tumor cells.

PubMed