Sunday, July 22, 2007

Selection and use of anti-infective agents for intra-abdominal infections

Selection and use of anti-infective agents for intra-abdominal infections

Arq Gastroenterol. 2007

Coelho JC, Baretta GA, Okawa L.
Serviço de Cirurgia do Aparelho Digestivo, Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, PR.


Dr. Júlio C. U. Coelho Rua Bento Viana, 1140 – apt.2202 80240-110 – Curitiba, PR E-mail:

Headings: Abdomen. Infection. Cross infection. Anti-bacterial agents.

BACKGROUND: Intra-abdominal infections are common and are associated with elevated morbidity and mortality. The microorganisms that cause intra-abdominal infections are usually from the gastrointestinal flora, mainly E. coli and Bacteroides fragilis.

AIM: To present a review of the selection and use of antibiotics in intra-abdominal infections.

CONCLUSIONS: Appropriate use of antibiotics is essential to control infection and to reduce treatment failure. Antibiotics are initiated whenever intra-abdominal infection is suspected and the antimicrobial agents are selected based on the most common microorganisms involved. In addition, efficacy, cost, safety, and posologic regimen are considered for an appropriated selection. Antibiotic regimen is different whether the infection is acquired in the community or at hospital due to the more resistant flora in the latter.

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