Saturday, February 16, 2008

Gatifloxacin Produces Both Hypoglycemia and Hyperglycemia: A Retrospective Study

Gatifloxacin Produces Both Hypoglycemia and Hyperglycemia: A Retrospective Study.
Am J Med Sci. 2008 Feb

Haerian H, McHugh P, Brown R, Somes G, Solomon SS.
From Research (sss), Medical (hh, pm, sss), and Pharmacy Services, VAMC Memphis, Memphis, Tennessee; and the Departments of Medicine (hh, pm, sss), Pharmacology (sss), and Preventive Medicine (gs) of the College of Medicine and College of Pharmacy (rb), University of Tennessee, the Health Science Center, Memphis, Tennessee.

BACKGROUND: Gatifloxacin, until recently one of the most commonly prescribed antibiotics, has been shown to produce hypoglycemia.

METHODS: To further examine the effects of Gatifloxicin (G) on blood glucose (BS), we conducted a retrospective chart review on 264 inpatients, examining for both hypoglycemia and hyperglycemia, comparing G with another quinolone, Ciproflaxin (C), and nonquinolone, Ceftriaxone (R).

RESULTS: We found that of 292 patient encounters, 28 hypoglycemia and 48 hyperglycemic events occurred. Patients given G were 5 times as likely to become hypoglycemic as C

CONCLUSIONS: In summary, G was clearly associated with both hypoglycemia and hyperglycemia compared with C and R. The risk of hyperglycemia increased in the presence of DM, steroid use, and "sick enough" to be in the intensive care unit.

PMID: 18277115 [PubMed - as supplied by publisher]