Saturday, March 01, 2008

Antimicrobials as a contributory factor in oral candidosis - a brief overview

Antimicrobials as a contributory factor in oral candidosis - a brief overview

Oral Dis. 2008 Mar

Soysa NS, Samaranayake LP, Ellepola AN.
Division of Pharmacology, Department of Oral Medicine and Periodontology, Faculty of Dental Sciences, University of Peradeniya, Peradeniya, Sri Lanka; 2Oral Bio-Sciences, Faculty of Dentistry, University of Hong Kong, Hong Kong; 3Department of Bioclinical Sciences, Faculty of Dentistry, Health Sciences Center, Kuwait University, Kuwait

Dr NS Soysa, Division of Pharmacology, Department of Oral Medicine and Periodontology, Faculty of Dental Sciences, University of Peradeniya, Peradeniya, Sri Lanka. Tel: 94-81-2387500, Fax: 94-81-2388948, E-mail: niroshanis@pdn.ac.lk/hnsnit@yahoo.com

The advent of the human immunodeficiency virus infection and the increasing prevalence of compromised individuals in the community due to modern therapeutic advances have resulted in a resurgence of opportunistic infections, including oral candidosis, which is by far the most common oral fungal infection in man. Broad-spectrum antibiotics used in the treatment of a wide range of disease conditions have also been attributed as a predisposing factor of oral candidosis. In this mini review we discuss the research findings on the relationship between antibiotics and oral candidosis and possible mechanisms of pathogenicity following such therapy.

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