Thursday, November 15, 2012

Elaiomycins K and L, new azoxy antibiotics from Streptomyces sp. Tü 6399*

Elaiomycins K and L, new azoxy antibiotics from Streptomyces sp. Tü 6399

Nov 2012


Mikrobiologisches Institut, Universität Tübingen, Tübingen, Germany.


Elaiomycins K and L, two new azoxy-type antibiotics, were detected by HPLC-diode array screening in the culture filtrate extract of Streptomyces sp. Tü 6399. The structures were determined by high-resolution MS and 2-dimensional (1)H and (13)C correlated NMR spectroscopy including (15)N-NMR experiments and established these compounds as new members of the elaiomycin family. Both metabolites show a weak antibacterial activity against Bacillus subtilis and Staphylococcus lentus as well as against the phytophathogenic strain Xanthomonas campestris.The Journal of Antibiotics advance online publication, 14 November 2012; doi:10.1038/ja.2012.99.